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Oxidation of Tetracaine Hydrochloride by Chloramine-B in Acid Medium : Kinetic Modeling
Joint Authors
Shubha, Jayachamarajapura Pranesh
Puttaswamy,
Source
Advances in Physical Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tetracaine hydrochloride (TCH) is one of the potent local anaesthetics.
A kinetic study of oxidation of tetracaine hydrochloride by sodium N-chlorobenzenesulfonamide (chloramine-B or CAB) has been carried in HClO4 medium at 303 K.
The rate shows first-order dependence on [CAB]o, shows fractional–order dependence on [substrate]o, and is self-governing on acid concentration.
Decrease of dielectric constant of the medium, by adding methanol, increased the rate.
Variation of ionic strength and addition of benzenesulfonamide or NaCl have no significant effect on the rate.
The reaction was studied at different temperatures and the activation parameters have been evaluated.
The stoichiometry of the reaction was found to be 1 : 5 and the oxidation products were identified by spectral analysis.
The conjugate free acid C6H5SO2NHCl of CAB is postulated as the reactive oxidizing species.
The observed results have been explained by plausible mechanism and the related rate law has been deduced.
American Psychological Association (APA)
Shubha, Jayachamarajapura Pranesh& Puttaswamy,. 2014. Oxidation of Tetracaine Hydrochloride by Chloramine-B in Acid Medium : Kinetic Modeling. Advances in Physical Chemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456403
Modern Language Association (MLA)
Shubha, Jayachamarajapura Pranesh& Puttaswamy,. Oxidation of Tetracaine Hydrochloride by Chloramine-B in Acid Medium : Kinetic Modeling. Advances in Physical Chemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-456403
American Medical Association (AMA)
Shubha, Jayachamarajapura Pranesh& Puttaswamy,. Oxidation of Tetracaine Hydrochloride by Chloramine-B in Acid Medium : Kinetic Modeling. Advances in Physical Chemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456403