Heat Shock Proteins at the Crossroads between Cancer and Alzheimer’s Disease
Joint Authors
Lu, Rui-Chun
Tan, Lan
Tan, Meng-Shan
Yu, Jin-Tai
Wang, Hao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Heat shock proteins 70 and heat shock proteins 90 (Hsp70/90) have been implicated in many crucial steps of carcinogenesis: stabilizing oncogenic proteins, inhibiting programmed cell death and replicative senescence, induction of tumor angiogenesis, and activation of the invasion and metastasis.
Plenty of cancer related proteins have the ability of regulating the expression of Hsp70/90 through heat shock factor 1.
Cancer and Alzheimer’s disease (AD) have plenty of overlapping regions in molecular genetics and cell biology associated with Hsp70/90.
The Hsp70, as a protein stabilizer, has a cellular protection against neurodegeneration of the central nervous system, while Hsp90 promote neurodegenerative disorders indirectly through regulating the expression of Hsp70 and other chaperones.
All these make existing anticancer drugs target Hsp70/90 which might be used in AD therapy.
American Psychological Association (APA)
Wang, Hao& Tan, Meng-Shan& Lu, Rui-Chun& Yu, Jin-Tai& Tan, Lan. 2014. Heat Shock Proteins at the Crossroads between Cancer and Alzheimer’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-456423
Modern Language Association (MLA)
Wang, Hao…[et al.]. Heat Shock Proteins at the Crossroads between Cancer and Alzheimer’s Disease. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-456423
American Medical Association (AMA)
Wang, Hao& Tan, Meng-Shan& Lu, Rui-Chun& Yu, Jin-Tai& Tan, Lan. Heat Shock Proteins at the Crossroads between Cancer and Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-456423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456423