Pilot Study to Evaluate the Effect of Topical Dimethicone on Clinical Signs and Skin Barrier Function in Dogs with Naturally Occurring Atopic Dermatitis
Joint Authors
Pellicoro, C.
Ahrens, K.
Marsella, R.
Source
Veterinary Medicine International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the effects of a skin protectant solution (dimethicone 2%) on clinical signs and skin barrier function in canine atopic dermatitis (AD).
Eighteen dogs with AD were randomly divided into two groups, one received dimethicone and the other received the vehicle (cyclomethicone) on selected areas (pinnae, groin, and axillae) daily for 4 weeks.
Owners and investigators were blinded regarding group allocation.
Clinical efficacy was evaluated using a scoring system and skin barrier by measuring the transepidermal water loss.
Twelve dogs completed the study (50% drop rate in the vehicle and 20% in the dimethicone).
For clinical signs, analysis of variance showed an effect of time (P<0.005; day 0 > day 28) and region (axillae < groin < pinnae) but no effect of group or group × time interaction.
For transepidermal water loss, analysis of variance showed only a main effect of region (axillae > pinnae > groin).
Pearson found no correlation between transepidermal water loss and clinical scores.
In this pilot study dimethicone had no significant effect on clinical signs and transepidermal water loss in canine atopic dermatitis.
American Psychological Association (APA)
Pellicoro, C.& Marsella, R.& Ahrens, K.. 2013. Pilot Study to Evaluate the Effect of Topical Dimethicone on Clinical Signs and Skin Barrier Function in Dogs with Naturally Occurring Atopic Dermatitis. Veterinary Medicine International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456427
Modern Language Association (MLA)
Pellicoro, C.…[et al.]. Pilot Study to Evaluate the Effect of Topical Dimethicone on Clinical Signs and Skin Barrier Function in Dogs with Naturally Occurring Atopic Dermatitis. Veterinary Medicine International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456427
American Medical Association (AMA)
Pellicoro, C.& Marsella, R.& Ahrens, K.. Pilot Study to Evaluate the Effect of Topical Dimethicone on Clinical Signs and Skin Barrier Function in Dogs with Naturally Occurring Atopic Dermatitis. Veterinary Medicine International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456427