A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions
Joint Authors
Visekruna, Alexander
Steinhoff, Ulrich
Volkov, Anton
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The transcription factors of the Rel/NF-κB family function as key regulators of innate and adoptive immunity.
Tightly and temporally controlled activation of NF-κB-signalling pathways ensures prevention of harmful immune cell dysregulation, whereas a loss of control leads to pathological conditions such as severe inflammation, autoimmune disease, and inflammation-associated oncogenesis.
Five family members have been identified in mammals: RelA (p65), c-Rel, RelB, and the precursor proteins NF-κB1 (p105) and NF-κB2 (p100), that are processed into p50 and p52, respectively.
While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin.
In T-cell lymphocytes, certain genes essential for immune function such as Il2 and Foxp3 are directly regulated by c-Rel.
Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T-cell differentiation and effector functions.
Accordingly, c-Rel expression in T cells and antigen-presenting cells (APCs) controls a delicate balance between tolerance and immunity.
This review gives a selective overview on recent progress in understanding of diverse roles of c-Rel in regulating adaptive immunity.
American Psychological Association (APA)
Visekruna, Alexander& Volkov, Anton& Steinhoff, Ulrich. 2012. A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456450
Modern Language Association (MLA)
Visekruna, Alexander…[et al.]. A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-456450
American Medical Association (AMA)
Visekruna, Alexander& Volkov, Anton& Steinhoff, Ulrich. A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456450