AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5
Joint Authors
Mukhopadhyay, Debashis
Raychaudhuri, Mithu
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a transmembrane protein of undetermined function.
APP is cleaved by gamma-secretase that releases the APP intracellular domain (AICD) in the cytoplasm.
In vitro and in vivo studies have implicated the role of AICD in cell signaling and transcriptional regulation of Gsk3β, KAI1, BACE1, EGFR, and other proteins.
In this study, by overexpressing AICD in mouse neuroblastoma cell lines, we have demonstrated the alteration in the expressions of two proteins, patched homolog 1 (PTCH1), a receptor for sonic hedgehog signaling, and transient receptor potential cation channel subfamily C member 5 (TRPC5), a component of receptor-activated nonselective calcium permeant cation channel.
Our results indicate the possibility of regulation by AICD in developmental processes as well as in the maintenance of calcium homeostasis at the transcription level.
American Psychological Association (APA)
Raychaudhuri, Mithu& Mukhopadhyay, Debashis. 2010. AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456459
Modern Language Association (MLA)
Raychaudhuri, Mithu& Mukhopadhyay, Debashis. AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-456459
American Medical Association (AMA)
Raychaudhuri, Mithu& Mukhopadhyay, Debashis. AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456459