Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis
Joint Authors
Huraib, Ghaleb Bin
al-Asmari, Abdulrahman K.
Tariq, Muhammad
Arfin, Misbahul
Zouman, Abdulrahman
al-Harthi, Fahad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background/Aim.
Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk.
However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations.
We investigated this association in Saudi psoriasis patients.
Methods.
Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit.
Results.
The frequencies of alleles ε2, ε4, and genotypes ε3/ε4 and ε3/ε2 were significantly higher in psoriasis patients compared with those in controls.
The frequency of ε3 allele and ε3/ε3 genotype was significantly lower in patients.
Other genotypes, ε2/ε4, ε2/ε2, and ε4/ε4, were absent in both groups.
The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level.
Patients with APOE ε4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε2 had higher HDL cholesterol, and triglycerides.
Conclusion.
APOE alleles ε2, ε4, and genotypes ε2/ε3 and ε4/ε3 are associated with psoriasis and can be a risk factor while allele ε3 and genotype ε3/ε3 may be protective for psoriasis in Saudis.
Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients.
American Psychological Association (APA)
al-Harthi, Fahad& Huraib, Ghaleb Bin& Zouman, Abdulrahman& Arfin, Misbahul& Tariq, Muhammad& al-Asmari, Abdulrahman K.. 2014. Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456478
Modern Language Association (MLA)
al-Harthi, Fahad…[et al.]. Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-456478
American Medical Association (AMA)
al-Harthi, Fahad& Huraib, Ghaleb Bin& Zouman, Abdulrahman& Arfin, Misbahul& Tariq, Muhammad& al-Asmari, Abdulrahman K.. Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456478