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PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis
Joint Authors
Stravodimou, Athina
Du Pasquier, R.
Rausch, T.
Michel, P.
Cairoli, Anne
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Posttransplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of solid organ transplantation.
The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV).
Lymphomatoid granulomatosis (LG) is a rare, EBV-associated systemic angiodestructive lymphoproliferative disorder, which has rarely been described in patients with renal transplantation.
We report the case of a patient with renal transplantation for SLE, who presented, 9 months after renal transplantation, an EBV-associated LG limited to the intracranial structures that recovered completely after adjustment of her immunosuppressive treatment.
Nine years later, she developed a second PTLD disorder with central nervous system initial manifestation.
Workup revealed an EBV-positive PTLD Burkitt lymphoma, widely disseminated in most organs.
In summary, the reported patient presented two lymphoproliferative disorders (LG and Burkitt's lymphoma), both with initial neurological manifestation, at 9 years interval.
With careful reduction of the immunosuppression after the first manifestation and with the use of chemotherapy combined with radiotherapy after the second manifestation, our patient showed complete disappearance of neurologic symptoms and she is clinically well with good kidney function.
No recurrence has been observed by radiological imaging until now.
American Psychological Association (APA)
Stravodimou, Athina& Cairoli, Anne& Rausch, T.& Du Pasquier, R.& Michel, P.. 2012. PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-456488
Modern Language Association (MLA)
Stravodimou, Athina…[et al.]. PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis. Case Reports in Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-456488
American Medical Association (AMA)
Stravodimou, Athina& Cairoli, Anne& Rausch, T.& Du Pasquier, R.& Michel, P.. PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-456488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456488