Progress in the Total Synthesis of Rocaglamide
Joint Authors
Guo, Hui
Xie, Bing
Cai, Xiao-hua
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The first cyclopenta[b]benzofuran derivative, rocaglamide, from Aglaia elliptifolia, was found to exhibit considerable insecticidal activities and excellent potential as a therapeutic agent candidate in cancer chemotherapy; the genus Aglaia has been subjected to further investigation.
Both the structural complexity of rocaglamide and its significant activity make it an attractive synthetic target.
Stereoselective synthesis of the dense substitution pattern of these targets is a formidable synthetic challenge: the molecules bear five contiguous stereocenters and cis aryl groups on adjacent carbons.
In past years of effort, only a handful of completed total syntheses have been reported, evidence of the difficulties associated with the synthesis of rocaglate natural products.
The advance on total synthesis of rocaglamide was mainly reviewed from intramolecular cyclization and biomimetic cycloaddition approach.
American Psychological Association (APA)
Cai, Xiao-hua& Xie, Bing& Guo, Hui. 2011. Progress in the Total Synthesis of Rocaglamide. ISRN Organic Chemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-456497
Modern Language Association (MLA)
Cai, Xiao-hua…[et al.]. Progress in the Total Synthesis of Rocaglamide. ISRN Organic Chemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-456497
American Medical Association (AMA)
Cai, Xiao-hua& Xie, Bing& Guo, Hui. Progress in the Total Synthesis of Rocaglamide. ISRN Organic Chemistry. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-456497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456497