Immunohistochemical Evaluation of p63, E-Cadherin, Collagen I and III Expression in Lower Limb Wound Healing under Honey
Joint Authors
Das, Raunak Kumar
Dhara, Santanu
Banerjee, Provas
Chatterjee, Jyotirmoy
Basu, Shyamal Kumar
Barui, Ananya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Honey is recognized traditionally for its medicinal properties and also appreciated as a topical healing agent for infected and noninfected wounds.
This study evaluates impact of honey-based occlusive dressing on nonhealing (nonresponding to conventional antibiotics) traumatic lower limb wounds (n=34) through clinicopathological and immunohistochemical (e.g., expression of p63, E-cadherin, and Collagen I and III) evaluations to enrich the scientific validation.
Clinical findings noted the nonadherence of honey dressing with remarkable chemical debridement and healing progression within 11–15 days of postintervention.
Histopathologically, in comparison to preintervention biopsies, the postintervention tissues of wound peripheries demonstrated gradual normalization of epithelial and connective tissue features with significant changes in p63+ epithelial cell population, reappearance of membranous E-cadherin (P<.0001), and optimum deposition of collagen I and III (P<.0001).
Thus, the present study for the first time reports the impact of honey on vital protein expressions in epithelial and connective tissues during repair of nonhealing lower limb wounds.
American Psychological Association (APA)
Barui, Ananya& Banerjee, Provas& Das, Raunak Kumar& Basu, Shyamal Kumar& Dhara, Santanu& Chatterjee, Jyotirmoy. 2011. Immunohistochemical Evaluation of p63, E-Cadherin, Collagen I and III Expression in Lower Limb Wound Healing under Honey. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-456503
Modern Language Association (MLA)
Barui, Ananya…[et al.]. Immunohistochemical Evaluation of p63, E-Cadherin, Collagen I and III Expression in Lower Limb Wound Healing under Honey. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-456503
American Medical Association (AMA)
Barui, Ananya& Banerjee, Provas& Das, Raunak Kumar& Basu, Shyamal Kumar& Dhara, Santanu& Chatterjee, Jyotirmoy. Immunohistochemical Evaluation of p63, E-Cadherin, Collagen I and III Expression in Lower Limb Wound Healing under Honey. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-456503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456503