Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans
Joint Authors
Source
International Journal of Microbiology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Continuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR).
Despite the current understanding of major factors which contribute to MDR mechanisms, there are many lines of evidence suggesting that it is a complex interplay of multiple factors which may be contributed by still unknown mechanisms.
Coincidentally with the increased usage of antifungal drugs, the number of reports for antifungal drug resistance has also increased which further highlights the need for understanding novel molecular mechanisms which can be explored to combat MDR, namely, ROS, iron, hypoxia, lipids, morphogenesis, and transcriptional and signaling networks.
Considering the worrying evolution of MDR and significance of C.
albicans being the most prevalent human fungal pathogen, this review summarizes these new regulatory mechanisms which could be exploited to prevent MDR development in C.
albicans as established from recent studies.
American Psychological Association (APA)
Hameed, Saif& Fatima, Zeeshan. 2013. Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans. International Journal of Microbiology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-456518
Modern Language Association (MLA)
Hameed, Saif& Fatima, Zeeshan. Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans. International Journal of Microbiology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-456518
American Medical Association (AMA)
Hameed, Saif& Fatima, Zeeshan. Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans. International Journal of Microbiology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-456518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456518