Current Views of Toll-Like Receptor Signaling Pathways
Joint Authors
Takeda, Kiyoshi
Yamamoto, Masahiro
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
On microbial invasion, the host immediately evokes innate immune responses.
Recent studies have demonstrated that Toll-like receptors (TLRs) play crucial roles in innate responses that lead not only to the clearance of pathogens but also to the efficient establishment of acquired immunity by directly detecting molecules from microbes.
In terms of intracellular TLR-mediated signaling pathways, cytoplasmic adaptor molecules containing Toll/IL-1R (TIR) domains play important roles in inflammatory immune responses through the production of proinflammatory cytokines, nitric oxide, and type I interferon, and upregulation of costimulatory molecules.
In this paper, we will describe our current understanding of the relationship between TLRs and their ligands derived from pathogens such as viruses, bacteria, fungi, and parasites.
Moreover, we will review the historical and current literature to describe the mechanisms behind TLR-mediated activation of innate immune responses.
American Psychological Association (APA)
Yamamoto, Masahiro& Takeda, Kiyoshi. 2010. Current Views of Toll-Like Receptor Signaling Pathways. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-456535
Modern Language Association (MLA)
Yamamoto, Masahiro& Takeda, Kiyoshi. Current Views of Toll-Like Receptor Signaling Pathways. Gastroenterology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-456535
American Medical Association (AMA)
Yamamoto, Masahiro& Takeda, Kiyoshi. Current Views of Toll-Like Receptor Signaling Pathways. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-456535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456535