Collagen XVII : A Shared Antigen in Neurodermatological Interactions?
Author
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Collagen XVII is a nonfibril-forming transmembrane collagen, which functions as both a matrix protein and a cell-surface receptor.
It is particularly copious in the skin, where it is known to be a structural component of hemidesmosomes.
In addition, collagen XVII has been found to be present in the central nervous system, thus offering an explanation for the statistical association between bullous pemphigoid, in which autoimmunity is directed against dermal collagen XVII, and neurological diseases.
In support of the hypothesis that collagen XVII serves as a shared antigen mediating an immune response between skin and brain, research on animal and human tissue, as well as numerous epidemiological and case studies, is presented.
American Psychological Association (APA)
Seppänen, Allan. 2013. Collagen XVII : A Shared Antigen in Neurodermatological Interactions?. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456559
Modern Language Association (MLA)
Seppänen, Allan. Collagen XVII : A Shared Antigen in Neurodermatological Interactions?. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456559
American Medical Association (AMA)
Seppänen, Allan. Collagen XVII : A Shared Antigen in Neurodermatological Interactions?. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456559