Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers
Joint Authors
Avino, Franca
Garzillo, Elpidio M.
Feola, Antonia
Lamberti, Monica
Giovane, Giancarlo
Tombolini, Vincenzo
Di Domenico, Marina
Porto, Stefania
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs.
The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity.
Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects.
In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.
American Psychological Association (APA)
Lamberti, Monica& Giovane, Giancarlo& Garzillo, Elpidio M.& Avino, Franca& Feola, Antonia& Porto, Stefania…[et al.]. 2014. Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456565
Modern Language Association (MLA)
Lamberti, Monica…[et al.]. Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-456565
American Medical Association (AMA)
Lamberti, Monica& Giovane, Giancarlo& Garzillo, Elpidio M.& Avino, Franca& Feola, Antonia& Porto, Stefania…[et al.]. Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456565