A Promise in the Treatment of Endometriosis : An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine
Joint Authors
Parasassi, Tiziana
Krasnowska, Ewa K.
Porpora, Maria Grazia
Nofroni, Italo
Ticino, Adele
Costa, Graziella
Piccioni, Maria Grazia
Lundeberg, Thomas
Imperiale, Ludovica
Brunelli, Roberto
Pittaluga, Eugenia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Urged by the unmet medical needs in endometriosis treatment, often with undesirable side effects, and encouraged by N-acetylcysteine (NAC) efficacy in an animal model of endometriosis and by the virtual absence of toxicity of this natural compound, we performed an observational cohort study on ovarian endometriosis.
NAC treatment or no treatment was offered to 92 consecutive Italian women referred to our university hospital with ultrasound confirmed diagnosis of ovarian endometriosis and scheduled to undergo laparoscopy 3 months later.
According to patients acceptance or refusal, NAC-treated and untreated groups finally comprised 73 and 72 endometriomas, respectively.
After 3 months, within NAC-treated patients cyst mean diameter was slightly reduced (-1.5 mm) versus a significant increase (+6.6 mm) in untreated patients (P=0.001).
Particularly, during NAC treatment, more cysts reduced and fewer cysts increased their size.
Our results are better than those reported after hormonal treatments.
Twenty-four NAC-treated patients—versus 1 within controls—cancelled scheduled laparoscopy due to cysts decrease/disappearance and/or relevant pain reduction (21 cases) or pregnancy (1 case).
Eight pregnancies occurred in NAC-treated patients and 6 in untreated patients.
We can conclude that NAC actually represents a simple effective treatment for endometriosis, without side effects, and a suitable approach for women desiring a pregnancy.
American Psychological Association (APA)
Porpora, Maria Grazia& Brunelli, Roberto& Costa, Graziella& Imperiale, Ludovica& Krasnowska, Ewa K.& Lundeberg, Thomas…[et al.]. 2013. A Promise in the Treatment of Endometriosis : An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456569
Modern Language Association (MLA)
Porpora, Maria Grazia…[et al.]. A Promise in the Treatment of Endometriosis : An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456569
American Medical Association (AMA)
Porpora, Maria Grazia& Brunelli, Roberto& Costa, Graziella& Imperiale, Ludovica& Krasnowska, Ewa K.& Lundeberg, Thomas…[et al.]. A Promise in the Treatment of Endometriosis : An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456569