Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma
Author
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Stromal invasion (invasive growth of tumor tissue into portal tracts and fibrous septa) is now recognized as the most important finding in the diagnosis of the well-differentiated type of early hepatocellular carcinomas (HCCs).
In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) the amount of fibrous components of stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation.
Knowledge of stromal invasion is also useful for a better understanding of the vasculature (hypovascular HCCs) and histological features (fatty change) of early HCCs.
Invasion of preexisting arteries and portal veins causes hypo-vascularity of HCCs.
Further, hypovascularity causes fatty change as a hypoxic change of cancer tissues.
American Psychological Association (APA)
Kondo, Fukuo. 2011. Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-456649
Modern Language Association (MLA)
Kondo, Fukuo. Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma. International Journal of Hepatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-456649
American Medical Association (AMA)
Kondo, Fukuo. Assessment of Stromal Invasion for Correct Histological Diagnosis of Early Hepatocellular Carcinoma. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-456649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456649