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The Relationship of HLA Class I and II Alleles and Haplotypes with Autism : A Case Control Study
Joint Authors
Awadallah, Sitalbanat
al-Hakbany, Manan
al-Ayadhi, Laila Y.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Earlier reports showed the relationship between autism and immune genes located in the human leukocyte antigen (HLA).
In this current study, we compared the HLA class I and class II alleles and haplotypes in 35 autistic children with 100 control subjects from Saudi Arabia, using PCR-SSP method and Luminex technology.
In class I the HLA-A*01 (P=0.03, OR 2.68), A*02 (P=0.001, OR 3.02) and HLA-B*07 (P=0.01, OR 3.27), were significantly associated with autism.
Also, the haplotype A*02-B*07 was significantly higher in autistic patients than in controls (P=0.007, OR 5.83).
In class II, DRB1*1104 was significantly higher in patients than in controls (P=0.001, OR 8.75).
The DQB1*0202 (P=0.001, OR 0.24), DQB1*0302 (P=0.001, OR 0.14), and DQB1*0501 (P=0.012, OR 0.25), were negatively associated with disease.
While the four-loci genotype study showed that A*01-B*07-DRB1*0701-DQB1*0602 (P=0.001, OR 41.9) and the A*31-B*51-DRB1*0103-DQB1*0302 (P=0.012, OR 4.8) are positively associated with autism among Saudi patients.
This is the first report on a foreseeable risk of association of HLA-B*07 allele with autism.
Thus, HLA-B*07 allele and the closely linked haplotype A*01 B*07 DRB1*0701 DQB1*0602 may serve as a marker for genetic susceptibility to autism in Saudis.
American Psychological Association (APA)
al-Hakbany, Manan& Awadallah, Sitalbanat& al-Ayadhi, Laila Y.. 2014. The Relationship of HLA Class I and II Alleles and Haplotypes with Autism : A Case Control Study. Autism Research and Treatment،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456685
Modern Language Association (MLA)
al-Hakbany, Manan…[et al.]. The Relationship of HLA Class I and II Alleles and Haplotypes with Autism : A Case Control Study. Autism Research and Treatment No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-456685
American Medical Association (AMA)
al-Hakbany, Manan& Awadallah, Sitalbanat& al-Ayadhi, Laila Y.. The Relationship of HLA Class I and II Alleles and Haplotypes with Autism : A Case Control Study. Autism Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456685