Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women
Joint Authors
Wenzlaff, Angela S.
Van Dyke, Alison L.
Land, Susan
Schwartz, Ann G.
Iyer, Priyanka
Cote, Michele L.
Abrams, Judith
Source
Journal of Cancer Epidemiology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cases; 103 controls) women.
Two TERT region SNPs, rs2075786 and rs2853677, conferred an increased risk of developing NSCLC, especially among African American women, and TERT-rs2735940 was associated with a decreased risk of lung cancer among African Americans.
Five of the 20 GHR polymorphisms and SEPP1-rs6413428 were associated with a marginally increased risk of NSCLC among Caucasians.
Random forest analysis reinforced the importance of GHR among Caucasians and identified AMACR, TERT, and GHR among African Americans, which were also significant using gene-based risk scores.
Smoking-SNP interactions were explored, and haplotypes in TERT and GHR associated with NSCLC risk were identified.
The roles of TERT, GHR, AMACR and SEPP1 genes in lung carcinogenesis warrant further exploration.
American Psychological Association (APA)
Van Dyke, Alison L.& Cote, Michele L.& Wenzlaff, Angela S.& Abrams, Judith& Land, Susan& Iyer, Priyanka…[et al.]. 2010. Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. Journal of Cancer Epidemiology،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-456693
Modern Language Association (MLA)
Van Dyke, Alison L.…[et al.]. Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. Journal of Cancer Epidemiology No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-456693
American Medical Association (AMA)
Van Dyke, Alison L.& Cote, Michele L.& Wenzlaff, Angela S.& Abrams, Judith& Land, Susan& Iyer, Priyanka…[et al.]. Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. Journal of Cancer Epidemiology. 2010. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-456693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456693