Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family
Joint Authors
Herrador, Antonio
Becuwe, Michel
Vincent, Olivier
Léon, Sébastien
Haguenauer-Tsapis, Rosine
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
In metazoans, proteins of the arrestin family are key players of G-protein-coupled receptors (GPCRS) signaling and trafficking.
Following stimulation, activated receptors are phosphorylated, thus allowing the binding of arrestins and hence an “arrest” of receptor signaling.
Arrestins act by uncoupling receptors from G proteins and contribute to the recruitment of endocytic proteins, such as clathrin, to direct receptor trafficking into the endocytic pathway.
Arrestins also serve as adaptor proteins by promoting the recruitment of ubiquitin ligases and participate in the agonist-induced ubiquitylation of receptors, known to have impact on their subcellular localization and stability.
Recently, the arrestin family has expanded following the discovery of arrestin-related proteins in other eukaryotes such as yeasts or fungi.
Surprisingly, most of these proteins are also involved in the ubiquitylation and endocytosis of plasma membrane proteins, thus suggesting that the role of arrestins as ubiquitin ligase adaptors is at the core of these proteins' functions.
Importantly, arrestins are themselves ubiquitylated, and this modification is crucial for their function.
In this paper, we discuss recent data on the intricate connections between arrestins and the ubiquitin pathway in the control of endocytosis.
American Psychological Association (APA)
Becuwe, Michel& Herrador, Antonio& Haguenauer-Tsapis, Rosine& Vincent, Olivier& Léon, Sébastien. 2012. Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-456736
Modern Language Association (MLA)
Becuwe, Michel…[et al.]. Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family. Biochemistry Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-456736
American Medical Association (AMA)
Becuwe, Michel& Herrador, Antonio& Haguenauer-Tsapis, Rosine& Vincent, Olivier& Léon, Sébastien. Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-456736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456736