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RP-HPLC Method for Determination of Several NSAIDs and Their Combination Drugs
Joint Authors
Patel, Prinesh N.
Modh, Sudipkumar C.
Chaudhari, Jainishkumar R.
Samanthula, Gananadhamu
Shrigod, Vishalkumar
Source
Chromatography Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
An RP-HPLC method for simultaneous determination of 9 NSAIDs (paracetamol, salicylic acid, ibuprofen, naproxen, aceclofenac, diclofenac, ketorolac, etoricoxib, and aspirin) and their commonly prescribed combination drugs (thiocolchicoside, moxifloxacin, clopidogrel, chlorpheniramine maleate, dextromethorphan, and domperidone) was established.
The separation was performed on Kromasil C18 (250 × 4.6 mm, 5 μm) at 35°C using 15 mM phosphate buffer pH 3.25 and acetonitrile with gradient elution at a flow rate of 1.1 mL/min.
The detection was performed by a diode array detector (DAD) at 230 nm with total run time of 30 min.
Calibration curves were linear with correlation coefficients of determination r2>0.999.
Limit of detection (LOD) and Limit of quantification (LOQ) ranged from 0.04 to 0.97 μg/mL and from 0.64 to 3.24 μg/mL, respectively.
As an application tool of quality by design, full factorial experimental design was used for the testing of robustness of the method.
The prediction profiler correlating various parameters and responses was established from the results of design of experiments (DOE).
American Psychological Association (APA)
Patel, Prinesh N.& Samanthula, Gananadhamu& Shrigod, Vishalkumar& Modh, Sudipkumar C.& Chaudhari, Jainishkumar R.. 2013. RP-HPLC Method for Determination of Several NSAIDs and Their Combination Drugs. Chromatography Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-456748
Modern Language Association (MLA)
Patel, Prinesh N.…[et al.]. RP-HPLC Method for Determination of Several NSAIDs and Their Combination Drugs. Chromatography Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-456748
American Medical Association (AMA)
Patel, Prinesh N.& Samanthula, Gananadhamu& Shrigod, Vishalkumar& Modh, Sudipkumar C.& Chaudhari, Jainishkumar R.. RP-HPLC Method for Determination of Several NSAIDs and Their Combination Drugs. Chromatography Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-456748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456748