Interaction between Mitochondria and the Endoplasmic Reticulum : Implications for the Pathogenesis of Type 2 Diabetes Mellitus
Joint Authors
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are closely associated with β-cell dysfunction and peripheral insulin resistance.
Thus, each of these factors contributes to the development of type 2 diabetes mellitus (DM).
The accumulated evidence reveals structural and functional communications between mitochondria and the ER.
It is now well established that ER stress causes apoptotic cell death by disturbing mitochondrial Ca2+ homeostasis.
In addition, recent studies have shown that mitochondrial dysfunction causes ER stress.
In this paper, we summarize the roles that mitochondrial dysfunction and ER stress play in the pathogenesis of type 2 DM.
Structural and functional communications between mitochondria and the ER are also discussed.
Finally, we focus on recent findings supporting the hypothesis that mitochondrial dysfunction and the subsequent induction of ER stress play important roles in the pathogenesis of type 2 DM.
American Psychological Association (APA)
Leem, Jaechan& Koh, Eun Hee. 2011. Interaction between Mitochondria and the Endoplasmic Reticulum : Implications for the Pathogenesis of Type 2 Diabetes Mellitus. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456759
Modern Language Association (MLA)
Leem, Jaechan& Koh, Eun Hee. Interaction between Mitochondria and the Endoplasmic Reticulum : Implications for the Pathogenesis of Type 2 Diabetes Mellitus. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-456759
American Medical Association (AMA)
Leem, Jaechan& Koh, Eun Hee. Interaction between Mitochondria and the Endoplasmic Reticulum : Implications for the Pathogenesis of Type 2 Diabetes Mellitus. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456759