Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs Using N-Bromosuccinimide and Indigo Carmine Dye
Joint Authors
Abdelmageed, Osama H.
El Hamd, Mohamed A.
Askal, Hassan F.
Derayea, Sayed M.
Source
International Journal of Spectroscopy
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Indirect spectrophotometric method is described for quantification of five of 1,4-dihydropyridine (1,4-DHP) drugs using N-bromosuccinimide (NBS) with the aid of indigo carmine (INC) dye.
The method is based on addition of known excess of NBS to an acidified solution of 1,4-DHP drugs and determining the residual of NBS through its ability to bleach the colour of the used dye; the amount of NBS that reacted corresponded to the amount of drugs.
Beer’s law is obeyed in the concentration range 1.25–13.00 μg/mL.
Good correlation coefficients (0.998-0.999) were found between the absorbance values and the corresponding concentrations.
Limits of detections ranged from 0.141 to 0.500 μg/mL.
The proposed method was successfully applied to the analysis of dosage forms; percent of recoveries ranged from 97.31 to 99.46% without interference from any common excipients.
The statistical comparison by Student’s t-test and variance ratio F-test showed no significant difference between the proposed and official or reported methods.
American Psychological Association (APA)
El Hamd, Mohamed A.& Derayea, Sayed M.& Abdelmageed, Osama H.& Askal, Hassan F.. 2013. Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs Using N-Bromosuccinimide and Indigo Carmine Dye. International Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456767
Modern Language Association (MLA)
El Hamd, Mohamed A.…[et al.]. Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs Using N-Bromosuccinimide and Indigo Carmine Dye. International Journal of Spectroscopy No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456767
American Medical Association (AMA)
El Hamd, Mohamed A.& Derayea, Sayed M.& Abdelmageed, Osama H.& Askal, Hassan F.. Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs Using N-Bromosuccinimide and Indigo Carmine Dye. International Journal of Spectroscopy. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456767