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New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals : In Vitro and In Vivo Studies and the Underlying Mechanisms
Joint Authors
Singh, Madhulika
Shukla, Yogeshwer
Suman, Shankar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Skin cancer is still a major cause of morbidity and mortality worldwide.
Skin overexposure to ultraviolet irradiations, chemicals, and several viruses has a capability to cause severe skin-related disorders including immunosuppression and skin cancer.
These factors act in sequence at various steps of skin carcinogenesis via initiation, promotion, and/or progression.
These days cancer chemoprevention is recognized as the most hopeful and novel approach to prevent, inhibit, or reverse the processes of carcinogenesis by intervention with natural products.
Phytochemicals have antioxidant, antimutagenic, anticarcinogenic, and carcinogen detoxification capabilities thereby considered as efficient chemopreventive agents.
Considerable efforts have been done to identify the phytochemicals which may possibly act on one or several molecular targets that modulate cellular processes such as inflammation, immunity, cell cycle progression, and apoptosis.
Till date several phytochemicals in the light of chemoprevention have been studied by using suitable skin carcinogenic in vitro and in vivo models and proven as beneficial for prevention of skin cancer.
This revision presents a comprehensive knowledge and the main molecular mechanisms of actions of various phytochemicals in the chemoprevention of skin cancer.
American Psychological Association (APA)
Singh, Madhulika& Suman, Shankar& Shukla, Yogeshwer. 2014. New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals : In Vitro and In Vivo Studies and the Underlying Mechanisms. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-456792
Modern Language Association (MLA)
Singh, Madhulika…[et al.]. New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals : In Vitro and In Vivo Studies and the Underlying Mechanisms. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-456792
American Medical Association (AMA)
Singh, Madhulika& Suman, Shankar& Shukla, Yogeshwer. New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals : In Vitro and In Vivo Studies and the Underlying Mechanisms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-456792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456792