Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men
Joint Authors
Tuck, Stephen P.
Vila, Josephine
Cooper, Cyrus
Datta, Harish K.
Dennison, Elaine
Varanasi, Satya S.
Mastana, Sarabjit S.
Francis, Roger M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The association of bone morphogenetic protein 2 (BMP2) with BMD and risk of fracture was suggested by a recent linkage study, but subsequent studies have been contradictory.
We report the results of a study of the relationship between BMP2 genotypes and BMD, annual change in BMD, and risk of fracture in male subjects.
Materials and Methods.
We tested three single-nucleotide polymorphisms (SNPs) across the BMP2 gene, including Ser37Ala SNP, in 342 Caucasian Englishmen, comprising 224 control and 118 osteoporotic subjects.
Results.
BMP2 SNP1 (Ser37Ala) genotypes were found to have similar low frequency in control subjects and men with osteoporosis.
The major informative polymorphism, BMP2 SNP3 (Arg190Ser), showed no statistically significant association with weight, height, BMD, change in BMD at hip or lumbar spine, and risk of fracture.
Conclusion.
There were no genotypic or haplotypic effects of the BMP2 candidate gene on BMD, change in BMD, or fracture risk identified in this cohort.
American Psychological Association (APA)
Varanasi, Satya S.& Tuck, Stephen P.& Mastana, Sarabjit S.& Dennison, Elaine& Cooper, Cyrus& Vila, Josephine…[et al.]. 2011. Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men. Journal of Osteoporosis،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-456795
Modern Language Association (MLA)
Varanasi, Satya S.…[et al.]. Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men. Journal of Osteoporosis No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-456795
American Medical Association (AMA)
Varanasi, Satya S.& Tuck, Stephen P.& Mastana, Sarabjit S.& Dennison, Elaine& Cooper, Cyrus& Vila, Josephine…[et al.]. Lack of Association of Bone Morphogenetic Protein 2 Gene Haplotypes with Bone Mineral Density, Bone Loss, or Risk of Fractures in Men. Journal of Osteoporosis. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-456795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456795
