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The Study of Release of Chlorhexidine from Preparations with Modified Thermosensitive Poly-N-isopropylacrylamide Microspheres
Joint Authors
Voncina, Bojana
Kokol, Vanja
Musial, Witold
Pluta, Janusz
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The aim of this study was to investigate and compare the release rates of chlorhexidine (CX) base entrapped in the polymeric beads of modified poly-N-isopropylacrylamides (pNIPAMs) at temperatures below and over the volume phase transition temperature (VPTT) of synthesized polymers: pNIPAM-A with terminal anionic groups resulting from potassium persulfate initiator, pNIPAM-B with cationic amidine terminal groups, and pNIPAM-C comprising anionic terminals, but with increased hydrophobicity maintained by the N-tert-butyl functional groups.
The preparations, assessed in vitro below the VPTT, release an initial burst of CX at different time periods between 120 and 240 min, followed by a period of 24 h, when the rate of release remains approximately constant, approaching the zero-order kinetics; the release rates for the polymers beads are as follows: pNIPAM-C>pNIPAM-B>pNIPAM-A.
The pattern of release rates at temperature over the VPTT is as follows: pNIPAM-C>pNIPAM-A>pNIPAM-B.
In the presence of pNIPAM-C, the duration between the start of the release and the attained minimal inhibitory concentration (MIC) for most of the microbes, in conditions over the VPTT, increased from 60 to 90 min.
The release prolongation could be ascribed to some interactions between the practically insoluble CX particle and the hydrophobic functional groups of the polymer.
American Psychological Association (APA)
Musial, Witold& Voncina, Bojana& Pluta, Janusz& Kokol, Vanja. 2012. The Study of Release of Chlorhexidine from Preparations with Modified Thermosensitive Poly-N-isopropylacrylamide Microspheres. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456820
Modern Language Association (MLA)
Musial, Witold…[et al.]. The Study of Release of Chlorhexidine from Preparations with Modified Thermosensitive Poly-N-isopropylacrylamide Microspheres. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-456820
American Medical Association (AMA)
Musial, Witold& Voncina, Bojana& Pluta, Janusz& Kokol, Vanja. The Study of Release of Chlorhexidine from Preparations with Modified Thermosensitive Poly-N-isopropylacrylamide Microspheres. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456820