CD8 T Cells and Toxoplasma gondii : A New Paradigm
Joint Authors
Gigley, Jason P.
Bhadra, Rajarshi
Khan, Imtiaz A.
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CD8 T cells are essential for control of Toxoplasma gondii infection.
Once activated they undergo differentiation into short-lived effector and memory precursor effector cells.
As effector cells, CD8 T cells exert immune pressure on the parasite via production of inflammatory cytokines and through their cytolytic activity.
Once immune control has been established, the parasite encysts and develops into chronic infection regulated by the memory CD8 T-cell population.
Several signals are needed for this process to be initiated and for development of fully differentiated memory CD8 T cells.
With newly developed tools including CD8 T-cell tetramers and TCR transgenic mice, dissecting the biology behind T.
gondii-specific CD8 T-cell responses can now be more effectively addressed.
In this paper, we discuss what is known about the signals required for effective T.
gondii-specific CD8 T-cell development, their differentiation, and effector function.
American Psychological Association (APA)
Gigley, Jason P.& Bhadra, Rajarshi& Khan, Imtiaz A.. 2011. CD8 T Cells and Toxoplasma gondii : A New Paradigm. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456831
Modern Language Association (MLA)
Gigley, Jason P.…[et al.]. CD8 T Cells and Toxoplasma gondii : A New Paradigm. Journal of Parasitology Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-456831
American Medical Association (AMA)
Gigley, Jason P.& Bhadra, Rajarshi& Khan, Imtiaz A.. CD8 T Cells and Toxoplasma gondii : A New Paradigm. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456831