In Vivo Antioxidant Activity of Topical Cream of Cassia tora L. Leaves Extract

Joint Authors

Kansara, Niraj P.
Badiger, A. M.
Rathore, D. S.
Gupta, V.

Source

Dataset Papers in Pharmacology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-08-09

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Pharmacology

Abstract EN

Objective.

The aim of study was to determine the in vivo antioxidant activity of newly formulated O/W cream of methanolic extract of Cassia tora L.

leaves.

Methods.

Oil in water (O/W) creams (0.05%, 0.1%, and 0.2%), cream base, methanolic extract of C.

tora L.

leaves (CTM), and standard (0.05% tretinoin cream) were screened for in vivo antioxidant activity.

The ultraviolet- (UV-) B-induced rats were treated with different standard, O/W creams, cream base, and methanolic extract of Cassia tora L.

leaves (CTM).

The parameters like lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels were assessed.

Results.

The result of acute dermal toxicity shows that the creams were safe up to 2000 mg/kg (topically).

Exposure of ultraviolet light of medium wave (UV-B light) decreased the level of GSH, CAT, and SOD and increased the LPO level.

Concluding Remarks.

We conclude that topical O/W creams of C.

tora L.

prevent the oxidative stress induced in rats by exposure to UV-B light by virtue of its in vivo antioxidant property, and these findings help to understand the mechanism of the antipsoriatic activity of O/W creams of C.

tora L.

in UV-B-induced psoriasis in the rat.

American Psychological Association (APA)

Gupta, V.& Rathore, D. S.& Kansara, Niraj P.& Badiger, A. M.. 2012. In Vivo Antioxidant Activity of Topical Cream of Cassia tora L. Leaves Extract. Dataset Papers in Pharmacology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456846

Modern Language Association (MLA)

Gupta, V.…[et al.]. In Vivo Antioxidant Activity of Topical Cream of Cassia tora L. Leaves Extract. Dataset Papers in Pharmacology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-456846

American Medical Association (AMA)

Gupta, V.& Rathore, D. S.& Kansara, Niraj P.& Badiger, A. M.. In Vivo Antioxidant Activity of Topical Cream of Cassia tora L. Leaves Extract. Dataset Papers in Pharmacology. 2012. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456846

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-456846