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Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MSMS
Joint Authors
Abdel-Daim, Mohamed M.
El-Lakkany, Naglaa M.
Hammam, Olfat A.
Sabra, Abdel-Nasser A.
al-Sayed, Eman
Seif el-Din, Sayed H.
Martiskainen, Olli
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The hepatoprotective and antioxidant activity of Bauhinia hookeri ethanol extract (BHE) against CCl4-induced liver injury was investigated in mice.
BHE was administered (500 and 1000 mg/kg/day) along with CCl4 for 6 weeks.
The hepatic marker enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were determined in the serum.
The antioxidant parameters: glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GST), and malondialdehyde (MDA) were estimated in the liver homogenate.
BHE treatment significantly inhibited the CCl4-induced increase in ALT (44 and 64%), AST (36 and 46%), ALP (28 and 42%), and MDA (39 and 51%) levels at the tested doses, respectively.
Moreover, BHE treatment markedly increased the activity of antioxidant parameters GSH, GPx, GR, GST, and SOD.
Histological observations confirmed the strong hepatoprotective activity.
These results suggest that a dietary supplement of BHE could exert a beneficial effect against oxidative stress and various liver diseases by enhancing the antioxidant defense status, reducing lipid peroxidation, and protecting against the pathological changes of the liver.
The hepatoprotective activity of BHE is mediated, at least in part, by the antioxidant effect of its constituents.
The active constituents of BHE were identified by HPLC-PDA-ESI/MS/MS.
American Psychological Association (APA)
al-Sayed, Eman& Martiskainen, Olli& Seif el-Din, Sayed H.& Sabra, Abdel-Nasser A.& Hammam, Olfat A.& El-Lakkany, Naglaa M.…[et al.]. 2014. Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MSMS. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-456869
Modern Language Association (MLA)
al-Sayed, Eman…[et al.]. Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MSMS. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-456869
American Medical Association (AMA)
al-Sayed, Eman& Martiskainen, Olli& Seif el-Din, Sayed H.& Sabra, Abdel-Nasser A.& Hammam, Olfat A.& El-Lakkany, Naglaa M.…[et al.]. Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MSMS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-456869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456869