Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster
Joint Authors
Tsai, Ruei-Lan
Pan, Tzu-Ming
Ho, Bing-Ying
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prevalence of oral tumor has exponentially increased in recent years; however, the effective therapies or prevention strategies are not sufficient.
Red mold rice is a traditional Chinese food, and several reports have demonstrated that red mold rice had an anti-tumor effect.
However, the possible anti-tumor mechanisms of the red mold rice are unclear.
In this study, we examined the anti-tumor effect of red mold rice on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced oral tumor in hamster.
The ethanol extract of red mold rice (RMRE) treatment significantly decreases the levels of DMBA-induced reactive oxygen species, nitro oxide and prostaglandin E2 than those of the lovastatin-treated group (P < .001).
Moreover, RMRE decreases the formation of oral tumor induced by DMBA.
Monacolin K, monascin, ankaflavin or other red mold rice metabolites had been reported to decrease inflammation and oxidative stress and exerted anti-tumor effects.
Therefore, we evaluated the anti-inflammation and anti-oxidative stress effects of monacolin K, monascin, ankaflavin and citrinin in lipopolysaccharide-treated RAW264.7 cells.
We found that RMRE reduced the LPS-induced nitrite levels in RAW264.7 cells better than monacolin K, monascin, ankaflavin or citrinin (P < .05).
American Psychological Association (APA)
Tsai, Ruei-Lan& Ho, Bing-Ying& Pan, Tzu-Ming. 2011. Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-456874
Modern Language Association (MLA)
Tsai, Ruei-Lan…[et al.]. Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-456874
American Medical Association (AMA)
Tsai, Ruei-Lan& Ho, Bing-Ying& Pan, Tzu-Ming. Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-456874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456874