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Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress
Joint Authors
Black, S. E.
Lanctôt, Krista L.
Andreazza, A. C.
Swardfager, W.
Khan, M. M.
Swartz, R. H.
Herrmann, Nathan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration.
Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination).
Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum.
Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status (F1,46=8.44, P=0.006).
IL-17 concentrations did not differ between subjects with and without depressive symptoms (F1,46=8.44, P=0.572); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms (F1,46=9.29, P=0.004).
In those subjects with depressive symptoms, IL-17 was associated with higher LPH (ρ=0.518, P=0.023) and lower IL-10 (ρ=-0.484, P=0.036), but not in those without.
In conclusion, poststroke depressive symptoms may be associated with cognitive vulnerability to IL-17 related pathways, involving an imbalance between proinflammatory and anti-inflammatory activity and increased oxidative stress.
American Psychological Association (APA)
Swardfager, W.& Herrmann, Nathan& Andreazza, A. C.& Swartz, R. H.& Khan, M. M.& Black, S. E.…[et al.]. 2014. Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456875
Modern Language Association (MLA)
Swardfager, W.…[et al.]. Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-456875
American Medical Association (AMA)
Swardfager, W.& Herrmann, Nathan& Andreazza, A. C.& Swartz, R. H.& Khan, M. M.& Black, S. E.…[et al.]. Poststroke Neuropsychiatric Symptoms : Relationships with IL-17 and Oxidative Stress. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456875