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Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression
Joint Authors
Kim, Chan-Sik
Lee, Yun Mi
Kim, Seon Gi
Jo, Kyuhyung
Shin, So Dam
Sohn, Eun Jin
Kim, Jin Sook
Kim, Junghyun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Retinal pathogenic angiogenesis in the eyes is a causative factor in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
This study was designed to examine the pathogenic role of the high-mobility group box-1 (HMGB1) protein and the inhibitory effect of ethyl pyruvate (EP), a well-known antioxidant substance, in retinal pathogenic angiogenesis in mice with oxygen-induced retinopathy (OIR), one of the animal models of proliferative ischemic retinopathy.
The OIR mouse model was used for our in vivo studies.
The mice were exposed to 75% oxygen from postnatal day 7 (P7) to P11, after which the mice were brought to room air and intraperitoneally injected with EP (50 mg/kg, or 100 mg/kg) for five days.
At P17, the mice were perfused with fluorescein isothiocyanate-dextran, and flat-mounted retinas were used to measure nonperfused and neovascular tufts.
In OIR mice, an intraperitoneal injection of EP reduced the nonperfused retinal area in the treatment group and significantly reduced the retinal neovascular tufts.
In addition, EP inhibited the overexpression of HMGB1 in the retinas of OIR mice.
These data suggest that EP could serve as an innovative pharmaceutical agent to prevent retinal neovascularization through inhibiting HMGB1 expression.
American Psychological Association (APA)
Lee, Yun Mi& Kim, Junghyun& Jo, Kyuhyung& Shin, So Dam& Kim, Chan-Sik& Sohn, Eun Jin…[et al.]. 2013. Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-456881
Modern Language Association (MLA)
Lee, Yun Mi…[et al.]. Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-456881
American Medical Association (AMA)
Lee, Yun Mi& Kim, Junghyun& Jo, Kyuhyung& Shin, So Dam& Kim, Chan-Sik& Sohn, Eun Jin…[et al.]. Ethyl Pyruvate Inhibits Retinal Pathogenic Neovascularization by Downregulating HMGB1 Expression. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-456881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456881