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Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Pharmaceutical Formulation by Thin-Layer Chromatographic-Densitometric Method
Joint Authors
Baldania, Sunil L.
Chhalotiya, Usmangani K.
Parmar, Ankit B.
Shah, Dimal A.
Bhatt, Kashyap K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A new, simple, accurate, and precise high-performance thin-layer chromatographic (HPTLC) method is described for simultaneous analysis of metoprolol succinate and olmesartan medoxomil in pharmaceutical formulations.
The separations were achieved on prepared TLC plates precoated with silica gel G 60 F254 and the plates were developed with methanol-ethyl acetate-toluene-glacial acetic acid 2.5 : 3 : 4.5 : 0.3%v/v/vas mobile phase.
Detection and evaluation of chromatograms were performed densitometrically at 224 nm.
The retention factor of metoprolol succinate and olmesartan medoxomil was 0.25 and 0.70, respectively.
The linear range was 1000–2250 ηg per spot for metoprolol succinate and 800–1800 ηg per spot for olmesartan medoxomil and the correlation coefficients (r) were 0.993 and 0.999, respectively.
The method was validated for linearity and range, specificity, precision, accuracy, and robustness, and the results were found to be within the acceptance criteria.
The method was successfully applied to the analysis of drugs in their capsule dosage form.
American Psychological Association (APA)
Baldania, Sunil L.& Parmar, Ankit B.& Bhatt, Kashyap K.& Shah, Dimal A.& Chhalotiya, Usmangani K.. 2012. Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Pharmaceutical Formulation by Thin-Layer Chromatographic-Densitometric Method. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456907
Modern Language Association (MLA)
Baldania, Sunil L.…[et al.]. Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Pharmaceutical Formulation by Thin-Layer Chromatographic-Densitometric Method. ISRN Analytical Chemistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-456907
American Medical Association (AMA)
Baldania, Sunil L.& Parmar, Ankit B.& Bhatt, Kashyap K.& Shah, Dimal A.& Chhalotiya, Usmangani K.. Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Pharmaceutical Formulation by Thin-Layer Chromatographic-Densitometric Method. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456907