Nucleosome Positioning
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions.
After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence.
Due to the development of modern DNA sequencing technology, genome-wide nucleosome mapping has been performed in a wide range of eukaryotic species.
Comparative analyses of the nucleosome positions have revealed that the nucleosome is more frequently formed in exonic than intronic regions, and that most of transcription start and translation (or transcription) end sites are located in nucleosome linker DNA regions, indicating that nucleosome positioning influences transcription initiation, transcription termination, and gene splicing.
In addition, nucleosomal DNA contains guanine and cytosine (G + C)-rich sequences and a high level of cytosine methylation.
Thus, the nucleosome positioning system has been conserved during eukaryotic evolution.
American Psychological Association (APA)
Nishida, Hiromi. 2012. Nucleosome Positioning. ISRN Molecular Biology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-456926
Modern Language Association (MLA)
Nishida, Hiromi. Nucleosome Positioning. ISRN Molecular Biology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-456926
American Medical Association (AMA)
Nishida, Hiromi. Nucleosome Positioning. ISRN Molecular Biology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-456926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456926