Effects of Atelocollagen Formulation Containing Oligonucleotide on Endothelial Permeability
Joint Authors
Kojima, Takashi
Sawada, Norimasa
Onodera, Jun
Hanai, Koji
Ota, Mika
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Atelocollagen is a major animal protein that is used as a highly biocompatible biomaterial.
To date, atelocollagen has been used as an effective drug delivery technology to sustain the release of antitumor proteins and to enhance the antitumor activity of oligonucleotides in in vivo models.
However, the biological effects of this technology are not fully understood.
In the present study, we investigated the effects of atelocollagen on endothelial paracellular barrier function.
An atelocollagen formulation containing oligonucleotides specifically increased the permeability of two types of endothelial cells, and the change was dependent on the molecular size, structure of the oligonucleotides used and the concentrations of the oligonucleotide and atelocollagen in the formulation.
An immunohistochemical examination revealed that the formulation had effects on the cellular skeleton and intercellular structure although it did not affect the expression of adherens junction or tight junction proteins.
These changes were induced through p38 MAP kinase signaling.
It is important to elucidate the biological functions of atelocollagen in order to be able to exploit its drug delivery properties.
American Psychological Association (APA)
Hanai, Koji& Kojima, Takashi& Ota, Mika& Onodera, Jun& Sawada, Norimasa. 2012. Effects of Atelocollagen Formulation Containing Oligonucleotide on Endothelial Permeability. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456946
Modern Language Association (MLA)
Hanai, Koji…[et al.]. Effects of Atelocollagen Formulation Containing Oligonucleotide on Endothelial Permeability. Journal of Drug Delivery No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-456946
American Medical Association (AMA)
Hanai, Koji& Kojima, Takashi& Ota, Mika& Onodera, Jun& Sawada, Norimasa. Effects of Atelocollagen Formulation Containing Oligonucleotide on Endothelial Permeability. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456946