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Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity
Joint Authors
Torban, Elena
Goodyer, Paul
Bitzan, Martin
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Focal segmental glomerulosclerosis refers to a set of particular histopathologic lesions in which steroid-resistant podocyte injury leads to patchy adhesions between the glomerular tuft and Bowman's capsule, followed by progressive glomerulosclerosis and proteinuric renal failure.
Because of the nonspecific nature of this lesion, it has been difficult to classify the various forms of primary nephrotic syndrome in children.
However, with the recognition of hereditary FSGS caused by mutations podocyte slit diaphragm genes, it is increasingly clear that the steroid-resistant form of FSGS that recurs in the renal allografts (R-FSGS) constitutes a distinct clinical entity.
Capitalizing on recent studies in which patients have been screened for slit diaphragm gene mutations, this review focuses on the natural history and pathogenesis of R-FSGS.
American Psychological Association (APA)
Torban, Elena& Bitzan, Martin& Goodyer, Paul. 2012. Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456980
Modern Language Association (MLA)
Torban, Elena…[et al.]. Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity. International Journal of Nephrology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-456980
American Medical Association (AMA)
Torban, Elena& Bitzan, Martin& Goodyer, Paul. Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456980