Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity

Joint Authors

Torban, Elena
Goodyer, Paul
Bitzan, Martin

Source

International Journal of Nephrology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-01-11

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Focal segmental glomerulosclerosis refers to a set of particular histopathologic lesions in which steroid-resistant podocyte injury leads to patchy adhesions between the glomerular tuft and Bowman's capsule, followed by progressive glomerulosclerosis and proteinuric renal failure.

Because of the nonspecific nature of this lesion, it has been difficult to classify the various forms of primary nephrotic syndrome in children.

However, with the recognition of hereditary FSGS caused by mutations podocyte slit diaphragm genes, it is increasingly clear that the steroid-resistant form of FSGS that recurs in the renal allografts (R-FSGS) constitutes a distinct clinical entity.

Capitalizing on recent studies in which patients have been screened for slit diaphragm gene mutations, this review focuses on the natural history and pathogenesis of R-FSGS.

American Psychological Association (APA)

Torban, Elena& Bitzan, Martin& Goodyer, Paul. 2012. Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456980

Modern Language Association (MLA)

Torban, Elena…[et al.]. Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity. International Journal of Nephrology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-456980

American Medical Association (AMA)

Torban, Elena& Bitzan, Martin& Goodyer, Paul. Recurrent Focal Segmental Glomerulosclerosis : A Discrete Clinical Entity. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456980

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-456980