Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies
Joint Authors
Petzold, Axel
Franciotta, Diego
van Pesch, Vincent
Fleming, John O.
Kuhle, Jens
Bennett, Jeffrey L.
Johnson, Michael H.
Killestein, Joep
Krasulova, Eva
Wolf, Christian
Furlan, Roberto
Teunissen, Charlotte E.
Federiksen, Jette L.
Hughes, Steve G.
Tumani, Hayrettin
Rejdak, Konrad
Berven, Frode S.
Waubant, Emmanuelle
Deisenhammer, Florian
Hintzen, Rogier Q.
Rajda, Cecilia
Hemmer, Bernhard
Jimenez, Connie R.
Schmidt, Hollie K.
Comabella, Manuel
Brundin, Lou
Magnone, Maria-Chiara
Giovannoni, Gavin
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases.
However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice.
Anti-aquaporin-4 antibodies in serum are currently useful for the diagnosis of neuromyelitis optica (NMO), but we could expect novel CSF biomarkers that help define prognosis and response to treatment for this disease.
One of the most critical factors in biomarker research is the inadequate powering of studies performed by single centers.
Collaboration between investigators is needed to establish large biobanks of well-defined samples.
A key issue in collaboration is to establish standardized protocols for biobanking to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by pre-analytical factors.
Here, consensus guidelines for CSF collection and biobanking are presented, based on the guidelines that have been published by the BioMS-eu network for CSF biomarker research.
We focussed on CSF collection procedures, pre-analytical factors and high quality clinical and paraclinical information.
Importantly, the biobanking protocols are applicable for CSF biobanks for research targeting any neurological disease.
American Psychological Association (APA)
Teunissen, Charlotte E.& Tumani, Hayrettin& Bennett, Jeffrey L.& Berven, Frode S.& Brundin, Lou& Comabella, Manuel…[et al.]. 2011. Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456999
Modern Language Association (MLA)
Teunissen, Charlotte E.…[et al.]. Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. Multiple Sclerosis International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-456999
American Medical Association (AMA)
Teunissen, Charlotte E.& Tumani, Hayrettin& Bennett, Jeffrey L.& Berven, Frode S.& Brundin, Lou& Comabella, Manuel…[et al.]. Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456999