PPARγ Networks in Cell Signaling : Update and Impact of Cyclic Phosphatidic Acid

Author

Tsukahara, Tamotsu

Source

Journal of Lipids

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-02-07

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine
Science

Abstract EN

Lysophospholipid (LPL) has long been recognized as a membrane phospholipid metabolite.

Recently, however, the LPL has emerged as a candidate for diagnostic and pharmacological interest.

LPLs include lysophosphatidic acid (LPA), alkyl glycerol phosphate (AGP), cyclic phosphatidic acid (cPA), and sphingosine-1-phosphate (S1P).

These biologically active lipid mediators serve to promote a variety of responses that include cell proliferation, migration, and survival.

These LPL-related responses are mediated by cell surface G-protein-coupled receptors and also intracellular receptor peroxisome proliferator-activated receptor gamma (PPARγ).

In this paper, we focus mainly on the most recent findings regarding the biological function of nuclear receptor-mediated lysophospholipid signaling in mammalian systems, specifically as they relate to health and diseases.

Also, we will briefly review the biology of PPARγ and then provide an update of lysophospholipids PPARγ ligands that are under investigation as a therapeutic compound and which are targets of PPARγ relevant to diseases.

American Psychological Association (APA)

Tsukahara, Tamotsu. 2013. PPARγ Networks in Cell Signaling : Update and Impact of Cyclic Phosphatidic Acid. Journal of Lipids،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-457010

Modern Language Association (MLA)

Tsukahara, Tamotsu. PPARγ Networks in Cell Signaling : Update and Impact of Cyclic Phosphatidic Acid. Journal of Lipids No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-457010

American Medical Association (AMA)

Tsukahara, Tamotsu. PPARγ Networks in Cell Signaling : Update and Impact of Cyclic Phosphatidic Acid. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-457010

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-457010