Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma
Joint Authors
Young, Gregory S.
Kusewitt, Donna F.
Oberyszyn, Tatiana M.
Tober, Kathleen L.
Riggenbach, Judith A.
Burns, Erin M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epidemiological studies support a link between cumulative sun exposure and cutaneous squamous cell carcinoma (SCC) development.
However, the presumed effects of extended ultraviolet light B (UVB) exposure on tumorigenesis in the sexes have not been formally investigated.
We examined differences in ultimate tumorigenesis at 25 weeks in mice exposed to UVB for either 10 or 25 weeks.
Additionally, we investigated the effect of continued UVB exposure on the efficacy of topical treatment with anti-inflammatory (diclofenac) or antioxidant (C E Ferulic or vitamin E) compounds on modulating tumorigenesis.
Vehicle-treated mice in the 25-week UVB exposure model exhibited an increased tumor burden and a higher percentage of malignant tumors compared to mice in the 10-week exposure model, which correlated with increases in total and mutant p53-positive epidermal cells.
Only topical diclofenac decreased tumor number and burden in both sexes regardless of UVB exposure length.
These data support the commonly assumed but not previously demonstrated fact that increased cumulative UVB exposure increases the risk of UVB-induced SCC development and can also affect therapeutic efficacies.
Our study suggests that cessation of UVB exposure by at-risk patients may decrease tumor development and that topical NSAIDs such as diclofenac may be chemopreventive.
American Psychological Association (APA)
Burns, Erin M.& Tober, Kathleen L.& Riggenbach, Judith A.& Kusewitt, Donna F.& Young, Gregory S.& Oberyszyn, Tatiana M.. 2013. Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma. Journal of Skin Cancer،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-457033
Modern Language Association (MLA)
Burns, Erin M.…[et al.]. Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma. Journal of Skin Cancer No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-457033
American Medical Association (AMA)
Burns, Erin M.& Tober, Kathleen L.& Riggenbach, Judith A.& Kusewitt, Donna F.& Young, Gregory S.& Oberyszyn, Tatiana M.. Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma. Journal of Skin Cancer. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-457033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457033