Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes
Joint Authors
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Diabetes mellitus (DM), a metabolic disorder characterized by hyperglycemia, is caused by insufficient insulin production due to excessive loss of pancreatic β cells (type I diabetes) or impaired insulin signaling due to peripheral insulin resistance (type II diabetes).
Pancreatic β cell is the only insulin-secreting cell type that has highly developed endoplasmic reticulum (ER) to cope with high demands of insulin synthesis and secretion.
Therefore, ER homeostasis is crucial to the proper function of insulin signaling.
Accumulating evidence suggests that deleterious ER stress and excessive intracellular lipids in nonadipose tissues, such as myocyte, cardiomyocyte, and hepatocyte, cause pancreatic β-cell dysfunction and peripheral insulin resistance, leading to type II diabetes.
The excessive deposition of lipid droplets (LDs) in specialized cell types, such as adipocytes, hepatocytes, and macrophages, has been found as a hallmark in ER stress-associated metabolic diseases, including obesity, diabetes, fatty liver disease, and atherosclerosis.
However, much work remains to be done in understanding the mechanism by which ER stress response regulates LD formation and the pathophysiologic role of ER stress-associated LD in metabolic disease.
This paper briefly summarizes the recent advances in ER stress-associated LD formation and its involvement in type II diabetes.
American Psychological Association (APA)
Zhang, Xuebao& Zhang, Kezhong. 2012. Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-457079
Modern Language Association (MLA)
Zhang, Xuebao& Zhang, Kezhong. Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes. Biochemistry Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-457079
American Medical Association (AMA)
Zhang, Xuebao& Zhang, Kezhong. Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-457079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457079