Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery
Joint Authors
Tura, Andrea
Kautzky-Willer, Alexandra
Pacini, Giovanni
Winhofer, Y.
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background and Aims.
Women with former gestational diabetes (fGDM) are characterized by impaired beta-cell function (BC).
Incretin hormones contribute to insulin secretion after oral administration of glucose.
We aimed to assess the possible role of incretins on altered insulin release in fGDM.
Materials and Methods.
We studied 104 fGDM women within 6 months after delivery and 35 healthy women after normal pregnancy (CNT) with a 75 g oral (OGTT) and a 0.33 g/kg intravenous (IVGTT) glucose test, both lasting 3 h.
The ratio of suprabasal areas under the concentration curves for glucose (dAUCGL) and C-peptide (dAUCCP) evaluated BC during OGTT (BCOG) and IVGTT (BCIV).
Incretin effect was computed in all fGDM and in fGDM with normal tolerance (fGDMNGT) and with impaired glucose regulation (fGDMIGR).
Results.
dAUCGL of fGDM was higher (P<0.0001) than CNT for both tests; while dAUCCP were not different.
BCOG and BCIV were lower in fGDM versus CNT (1.42±0.17nmolCP/mmolGLUC versus 2.53±0.61, P=0.015 and 0.41 ± 0.03 versus 0.68 ± 0.10, P=0.0006, respectively).
IE in CNT (66 ± 4 %) was not different from that of all fGDM (59 ± 3) and fGDMNGT (60±3), but higher than that of fGDMIGR (52±6; P=0.03).
IE normalized to BMI was 2.77±0.19 % m2/kg in CNT, higher than that of fGDMIGR (1.75±0.21; P=0.02) and also of fGDMNGT (2.33±0.11; P=0.038).
Conclusion.
Compromised IE characterizes fGDMIGR.
In both fGDM categories, regardless their glucose tolerance, IE normalized to BMI was reduced, signifying an intrinsic characteristic of fGDM.
Therefore, the diminished IE of fGDM seems to reflect an early abnormality of the general beta-cell dysfunction in the progression toward type 2 diabetes.
American Psychological Association (APA)
Pacini, Giovanni& Tura, Andrea& Winhofer, Y.& Kautzky-Willer, Alexandra. 2012. Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-457099
Modern Language Association (MLA)
Pacini, Giovanni…[et al.]. Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery. International Journal of Endocrinology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-457099
American Medical Association (AMA)
Pacini, Giovanni& Tura, Andrea& Winhofer, Y.& Kautzky-Willer, Alexandra. Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-457099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457099