Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery
Joint Authors
Parisi, Antonio
Caiazzo, Elisabetta
Mascolo, Nicola
Cicala, Carla
Maione, Francesco
Morello, Silvana
D'Acquisto, Fulvio
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Interleukin-17A (IL-17A), the most widely studied member of the IL-17 cytokine family, is a cytokine which emerged to be critical for host defense as well as in the pathogenesis of autoimmune disorders.
Moreover, IL-17A is involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and acute coronary syndrome and in the cardiovascular risk associated with systemic immunological disorders.
Consistent with this, we have recently shown that IL-17A increases human and murine platelet response to ADP.
In this study we expanded our previous observation and we describe for the first time an in vivo prothrombotic effect of the cytokine.
Our results show that IL-17A is synergic with a low FeCl3 concentration in inducing carotid thrombus in rats and suggest that the effect is likely related to a downregulation of CD39 vascular expression and hydrolyzing activity.
Our findings indicate that IL-17A might be an important molecule at the interface between hemostasis and inflammation.
American Psychological Association (APA)
Maione, Francesco& Parisi, Antonio& Caiazzo, Elisabetta& Morello, Silvana& D'Acquisto, Fulvio& Mascolo, Nicola…[et al.]. 2014. Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-457109
Modern Language Association (MLA)
Maione, Francesco…[et al.]. Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery. International Journal of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-457109
American Medical Association (AMA)
Maione, Francesco& Parisi, Antonio& Caiazzo, Elisabetta& Morello, Silvana& D'Acquisto, Fulvio& Mascolo, Nicola…[et al.]. Interleukin-17A Exacerbates Ferric Chloride-Induced Arterial Thrombosis in Rat Carotid Artery. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-457109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457109