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Antitumor Activity of Artemisinin and Its Derivatives : From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
Joint Authors
Crespo-Ortiz, Maria P.
Wei, Ming Q.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-22
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells.
Artemisinin and its analogs are naturally occurring antimalarials which have shown potent anticancer activity.
In primary cancer cultures and cell lines, their antitumor actions were by inhibiting cancer proliferation, metastasis, and angiogenesis.
In xenograft models, exposure to artemisinins substantially reduces tumor volume and progression.
However, the rationale for the use of artemisinins in anticancer therapy must be addressed by a greater understanding of the underlying mechanisms involved in their cytotoxic effects.
The primary targets for artemisinin and the chemical base for its preferential effects on heterologous tumor cells need yet to be elucidated.
The aim of this paper is to provide an overview of the recent advances and new development of this class of drugs as potential anticancer agents.
American Psychological Association (APA)
Crespo-Ortiz, Maria P.& Wei, Ming Q.. 2011. Antitumor Activity of Artemisinin and Its Derivatives : From a Well-Known Antimalarial Agent to a Potential Anticancer Drug. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-457116
Modern Language Association (MLA)
Crespo-Ortiz, Maria P.& Wei, Ming Q.. Antitumor Activity of Artemisinin and Its Derivatives : From a Well-Known Antimalarial Agent to a Potential Anticancer Drug. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-457116
American Medical Association (AMA)
Crespo-Ortiz, Maria P.& Wei, Ming Q.. Antitumor Activity of Artemisinin and Its Derivatives : From a Well-Known Antimalarial Agent to a Potential Anticancer Drug. Journal of Biomedicine and Biotechnology. 2011. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-457116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457116