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Aberrant Methylation in Promoters of GSTP1, p16, p14, and RASSF1A Genes in Smokers of North India
Joint Authors
Thapliyal, Shruti
Garg, Charu
Chandel, Avinash
Sidhu, Sukhjeet
Deep, Jagdeep S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Promoter hypermethylation plays an important role in the inactivation of tumor suppressor/metabolic genes during tumorigenesis.
The screening of high-risk population (smokers) for hypermethylation pattern in tumor suppressor/metabolic genes can be a good noninvasive biomarker tool, which should be included in prognosis so that therapeutic measures can be initiated at an early stage.
The purpose of this study was to determine the prevalence of aberrant promoter methylation of GSTP1, p16, p14, and RASSF1A genes in smokers and nonsmokers of North India.
Our study showed that compared with nonsmokers, smokers have an increased risk of hypermethylation in these genes.
We found that 57.3% of the smokers samples showed methylation for GSTP1, 38% for p16, 18% for p14, and 32% for RASSF1A.
Our population study allowed us to reveal the relationship between smoking and the subsequent appearance of an epigenetic change.
Smoking speeds up the hypermethylation of these genes, which are thus unable to express, making the person more susceptible to the risk of lung and other solid carcinomas.
Hypermethylation studies on DNA from two lung cancer cell lines (A549 and H460) were also done to compare the results, and the results are similar to samples of smokers.
American Psychological Association (APA)
Deep, Jagdeep S.& Sidhu, Sukhjeet& Chandel, Avinash& Thapliyal, Shruti& Garg, Charu. 2012. Aberrant Methylation in Promoters of GSTP1, p16, p14, and RASSF1A Genes in Smokers of North India. ISRN Pulmonology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-457123
Modern Language Association (MLA)
Deep, Jagdeep S.…[et al.]. Aberrant Methylation in Promoters of GSTP1, p16, p14, and RASSF1A Genes in Smokers of North India. ISRN Pulmonology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-457123
American Medical Association (AMA)
Deep, Jagdeep S.& Sidhu, Sukhjeet& Chandel, Avinash& Thapliyal, Shruti& Garg, Charu. Aberrant Methylation in Promoters of GSTP1, p16, p14, and RASSF1A Genes in Smokers of North India. ISRN Pulmonology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-457123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457123