Diagnostic Accuracy of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Evaluation of the Primary Tumor in Patients with Cholangiocarcinoma : A Meta-Analysis

Abstract EN

Objective.

To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for primary tumor evaluation in patients with cholangiocarcinoma (CCa).

Methods.

A comprehensive literature search of studies published through December 31, 2013, was performed.

Pooled sensitivity and specificity were calculated on a per patient based analysis.

Subgroup analyses considering the device used (PET versus PET/CT) and the localization of the primary tumor (intrahepatic cholangiocarcinoma (IH-CCa), extrahepatic cholangiocarcinoma (EH-CCa), and hilar cholangiocarcinoma (H-CCa)) were carried out.

Results.

Twenty-three studies including 1232 patients were included in the meta-analysis.

Pooled sensitivity and specificity of 18F-FDG-PET or PET/CT were 81% and 82%, respectively.

Pooled sensitivity and specificity, respectively, were 80% and 89% for PET, 82% and 75% for PET/CT, 95% and 83% for IH-CCa, 84% and 95% for H-CCa, and 76% and 74% for EH-CCa.

Conclusions. 18F-FDG-PET and PET/CT were demonstrated to be accurate diagnostic imaging methods for primary tumor evaluation in patients with CCa.

These tools have a better diagnostic accuracy in patients with IH-CCa than in patients with EH-CCa.

Further studies are needed to evaluate the accuracy of 18F-FDG-PET or PET/CT in patients with H-CCa.