A Systematic Review of the Utility of Residual Vein Obstruction Studies in Primary and Secondary Venous Thrombosis
Joint Authors
Janakiram, Murali
Billett, Henny H.
Sullivan, Matthew
Shcherba, Marina
Guo, Shuang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Residual vein obstruction (RVO), the persistence of venous thrombosis with time and often after anticoagulation, may indicate a systemic prothrombotic condition.
Prior studies have shown varying efficacy in using RVO as a risk factor for future venous thromboembolic (VTE) recurrence.
Methods.
To assess whether positive RVO imaging predicts recurrent VTE events, we performed a meta-analysis on studies in which patients with documented VTEs, anticoagulated for a minimum of 4 weeks, had repeat sonography to assess RVO and were subsequently followed for recurrent events.
Results.
Thirteen studies met inclusion criteria: 3531 patient VTE events with 3474 evaluable results were analyzed.
The presence of RVO was associated with recurrence in all VTE (OR 1.93; 95% CI: 1.29, 2.89) and secondary VTE (OR 2.78; 95% CI: 1.41, 5.5) but not for primary VTE (OR 1.35; 95% CI: 0.87, 2.08).
When cancer patients were eliminated from the secondary VTE group, there was no longer a significant association of RVO with VTE recurrence (OR 1.73; 95% CI: 0.81, 3.67) while in the subset of cancer patients, presence of RVO was associated with an increase in VTE recurrence risk (OR 5.14; 95% CI: 1.59, 16.65, P<0.006).
Conclusions.
We conclude that the presence of RVO is associated with recurrence in secondary VTE but not in primary VTE and that association may be driven by the subset with cancer.
American Psychological Association (APA)
Janakiram, Murali& Sullivan, Matthew& Shcherba, Marina& Guo, Shuang& Billett, Henny H.. 2013. A Systematic Review of the Utility of Residual Vein Obstruction Studies in Primary and Secondary Venous Thrombosis. Thrombosis،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-457141
Modern Language Association (MLA)
Janakiram, Murali…[et al.]. A Systematic Review of the Utility of Residual Vein Obstruction Studies in Primary and Secondary Venous Thrombosis. Thrombosis No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-457141
American Medical Association (AMA)
Janakiram, Murali& Sullivan, Matthew& Shcherba, Marina& Guo, Shuang& Billett, Henny H.. A Systematic Review of the Utility of Residual Vein Obstruction Studies in Primary and Secondary Venous Thrombosis. Thrombosis. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-457141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457141