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In Vivo Effects of Antiviral Protein Kinase C Modulators on Zebrafish Development and Survival
Joint Authors
Davis, Richard V.
Kulkosky, Joseph
McKernan, Lisa N.
Rhodes, Jennifer
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Clinical interventions using protein kinase C (PKC) modulators have been proposed for eradication of HIV-1-infected cellular reservoirs which persist in patients despite prolonged antiretroviral therapy.
The effects of some of these agents have not been assessed in a developing vertebrate model.
This study examines the developmental and toxicological effects of these compounds on zebrafish embryos and larvae.
Treatment of zebrafish through the first week of development with various PKC pathway modulators did not elicit gross physical defects or elevated incidences of death at lower doses.
Higher concentrations resulted in rapid death for both later-stage embryos and larvae.
Each compound had a threshold dose for lethality.
The defined nonlethal doses may be useful toward assessing the effects of modulating PKC activity on zebrafish development.
They may further provide some guidance for the potential dosing of PKC modulators in clinical trials toward the goal of HIV-1 reservoir eradication.
American Psychological Association (APA)
Davis, Richard V.& McKernan, Lisa N.& Rhodes, Jennifer& Kulkosky, Joseph. 2011. In Vivo Effects of Antiviral Protein Kinase C Modulators on Zebrafish Development and Survival. ISRN Toxicology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-457178
Modern Language Association (MLA)
Davis, Richard V.…[et al.]. In Vivo Effects of Antiviral Protein Kinase C Modulators on Zebrafish Development and Survival. ISRN Toxicology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-457178
American Medical Association (AMA)
Davis, Richard V.& McKernan, Lisa N.& Rhodes, Jennifer& Kulkosky, Joseph. In Vivo Effects of Antiviral Protein Kinase C Modulators on Zebrafish Development and Survival. ISRN Toxicology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-457178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457178