NK Cells and Psoriasis
Joint Authors
Gardiner, Clair M.
Dunphy, Sinéad
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques.
The immune system is now thought to play a major role in the development and pathogenesis of psoriasis with immune cells and cytokines influencing keratinocyte function.
Keratinocytes in turn, can activate and recruit immune cells leading to a positive feedback loop in disease.
Natural Killer (NK) cells are lymphocytes that are best known for killing virally infected and cancer cells.
However, evidence is emerging to support a role for NK cells in psoriasis.
NK cells are found in the inflammatory infiltrate in psoriatic skin lesions.
They can produce a range of inflammatory cytokines, many of which are important in the pathogenesis of psoriasis.
Recent genetic studies have identified a range of potential molecules relating to NK cell biology that are known to be important in psoriasis.
This paper will discuss the evidence, both cellular and genetic, for NK cell involvement in psoriasis.
American Psychological Association (APA)
Dunphy, Sinéad& Gardiner, Clair M.. 2011. NK Cells and Psoriasis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-457182
Modern Language Association (MLA)
Dunphy, Sinéad& Gardiner, Clair M.. NK Cells and Psoriasis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-457182
American Medical Association (AMA)
Dunphy, Sinéad& Gardiner, Clair M.. NK Cells and Psoriasis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-457182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457182