The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype)
Joint Authors
Rees, David Charles
Dalibalta, S.
Weiss, Erwin
Ellory, J. C.
Hannemann, A.
Gibson, John Stanley
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sickle cell disease (SCD) is one of the commonest severe inherited disorders, but specific treatments are lacking and the pathophysiology remains unclear.
Affected individuals account for well over 250,000 births yearly, mostly in the Tropics, the USA, and the Caribbean, also in Northern Europe as well.
Incidence in the UK amounts to around 12–15,000 individuals and is increasing, with approximately 300 SCD babies born each year as well as with arrival of new immigrants.
About two thirds of SCD patients are homozygous HbSS individuals.
Patients heterozygous for HbS and HbC (HbSC) constitute about a third of SCD cases, making this the second most common form of SCD, with approximately 80,000 births per year worldwide.
Disease in these patients shows differences from that in homozygous HbSS individuals.
Their red blood cells (RBCs), containing approximately equal amounts of HbS and HbC, are also likely to show differences in properties which may contribute to disease outcome.
Nevertheless, little is known about the behaviour of RBCs from HbSC heterozygotes.
This paper reviews what is known about SCD in HbSC individuals and will compare the properties of their RBCs with those from homozygous HbSS patients.
Important areas of similarity and potential differences will be emphasised.
American Psychological Association (APA)
Hannemann, A.& Weiss, Erwin& Rees, David Charles& Dalibalta, S.& Ellory, J. C.& Gibson, John Stanley. 2010. The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype). Anemia،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-457207
Modern Language Association (MLA)
Hannemann, A.…[et al.]. The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype). Anemia No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-457207
American Medical Association (AMA)
Hannemann, A.& Weiss, Erwin& Rees, David Charles& Dalibalta, S.& Ellory, J. C.& Gibson, John Stanley. The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype). Anemia. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-457207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457207