Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection
Joint Authors
Shun, Chia-Tung
Kao, John Y.
Yang, Jyh-Chin
Yang, Hung-Chih
Wang, Teh-Hong
Chien, Chiang-Ting
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The inflammasome/caspase-1 signaling pathway in immune cells plays a critical role in bacterial pathogenesis; however, the regulation of this pathway in the gastric epithelium during Helicobacter pylori infection is yet to be elucidated.
Here, we investigated the effect of catechins (CAs), sialic acid (SA), or combination of CA and SA (CASA) on H.
pylori-induced caspase-1-mediated epithelial damage, as well as H.
pylori colonization in vitro (AGS cells) and in vivo (BALB/c mice).
Our results indicate that the activity of caspase-1 and the expression of its downstream substrate IL-1β were upregulated in H.
pylori-infected AGS cells.
In addition, we observed increased oxidative stress, NADPH oxidase gp91phox, CD68, caspase-1/IL-1β, and apoptosis, but decreased autophagy, in the gastric mucosa of H.
pylori-infected mice.
We have further demonstrated that treatment with CASA led to synergistic anti-H.
pylori activity and was more effective than treatment with CA or SA alone.
In particular, treatment with CASA for 10 days eradicated H.
pylori infection in up to 95% of H.
pylori-infected mice.
Taken together, we suggest that the pathogenesis of H.
pylori involves a gastric epithelial inflammasome/caspase-1 signaling pathway, and our results show that CASA was able to attenuate this pathway and effectively eradicate H.
pylori infection.
American Psychological Association (APA)
Yang, Jyh-Chin& Yang, Hung-Chih& Shun, Chia-Tung& Wang, Teh-Hong& Chien, Chiang-Ting& Kao, John Y.. 2013. Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-457215
Modern Language Association (MLA)
Yang, Jyh-Chin…[et al.]. Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-457215
American Medical Association (AMA)
Yang, Jyh-Chin& Yang, Hung-Chih& Shun, Chia-Tung& Wang, Teh-Hong& Chien, Chiang-Ting& Kao, John Y.. Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-457215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457215