The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer
Joint Authors
Pollak, Michael
Nelson, Colleen C.
Lubik, Amy A.
Gunter, Jennifer H.
McKenzie, Ian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
An association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insulin and androgens may be reciprocally regulated are not well described.
Androgen-dependant gene pathways regulate the growth and maintenance of both normal and malignant prostate tissue, and androgen-deprivation therapy (ADT) in patients exploits this dependence when used to treat recurrent and metastatic prostate cancer resulting in tumour regression.
A major systemic side effect of ADT includes induction of key features of the metabolic syndrome and the consistent feature of hyperinsulinaemia.
Recent studies have specifically identified a correlation between elevated insulin and high-grade PCa and more rapid progression to castrate resistant disease.
This paper examines the relationship between insulin and androgens in the context of prostate cancer progression.
Prostate cancer patients present a promising cohort for the exploration of insulin stabilising agents as adjunct treatments for hormone deprivation or enhancers of chemosensitivity for treatment of advanced prostate cancer.
American Psychological Association (APA)
Gunter, Jennifer H.& Lubik, Amy A.& McKenzie, Ian& Pollak, Michael& Nelson, Colleen C.. 2012. The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer. Advances in Urology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457217
Modern Language Association (MLA)
Gunter, Jennifer H.…[et al.]. The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer. Advances in Urology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-457217
American Medical Association (AMA)
Gunter, Jennifer H.& Lubik, Amy A.& McKenzie, Ian& Pollak, Michael& Nelson, Colleen C.. The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-457217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457217