Role of Calcium and Mitochondria in MeHg-Mediated Cytotoxicity
Joint Authors
Vargas Barbosa, Nilda
Seeger, Rodrigo L.
Roos, Daniel
Puntel, Robson
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Methylmercury (MeHg) mediated cytotoxicity is associated with loss of intracellular calcium (Ca2+) homeostasis.
The imbalance in Ca2+ physiology is believed to be associated with dysregulation of Ca2+ intracellular stores and/or increased permeability of the biomembranes to this ion.
In this paper we summarize the contribution of glutamate dyshomeostasis in intracellular Ca2+ overload and highlight the mitochondrial dysfunctions induced by MeHg via Ca2+ overload.
Mitochondrial disturbances elicited by Ca2+ may involve several molecular events (i.e., alterations in the activity of the mitochondrial electron transport chain complexes, mitochondrial proton gradient dissipation, mitochondrial permeability transition pore (MPTP) opening, thiol depletion, failure of energy metabolism, reactive oxygen species overproduction) that could culminate in cell death.
Here we will focus on the role of oxidative stress in these phenomena.
Additionally, possible antioxidant therapies that could be effective in the treatment of MeHg intoxication are briefly discussed.
American Psychological Association (APA)
Roos, Daniel& Seeger, Rodrigo L.& Puntel, Robson& Vargas Barbosa, Nilda. 2012. Role of Calcium and Mitochondria in MeHg-Mediated Cytotoxicity. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-457234
Modern Language Association (MLA)
Roos, Daniel…[et al.]. Role of Calcium and Mitochondria in MeHg-Mediated Cytotoxicity. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-457234
American Medical Association (AMA)
Roos, Daniel& Seeger, Rodrigo L.& Puntel, Robson& Vargas Barbosa, Nilda. Role of Calcium and Mitochondria in MeHg-Mediated Cytotoxicity. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-457234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457234